2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
| 中文名称 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE |
|---|---|
| 中文同义词 | 2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺;2-氯-N-(3,4-二甲氧基苄基)乙酰胺;2-氯-N-[(3,4-二甲氧苯基)甲基]乙酰胺;乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-;UBA5抑制剂(DKM 2-93);2-氯-N-((3;4-二甲氧苯基)甲基)乙酰胺 |
| 英文名称 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE |
| 英文同义词 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE;CHEMBRDG-BB 9070724;2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide;Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-;Brn 2857211;N-(Dimethoxy-3,4 benzyl)-chloroacetamide;N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french];2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE) |
| CAS号 | 65836-72-8 |
| 分子式 | C11H14ClNO3 |
| 分子量 | 243.69 |
| EINECS号 | 604-604-1 |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 65836-72-8.mol |
| 结构式 |  |
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE 性质
| 熔点 | 116-118 °C(Solv: carbon tetrachloride (56-23-5)) |
|---|---|
| 沸点 | 425.7±45.0 °C(Predicted) |
| 密度 | 1.194±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥150mg/mL（615.54mM） |
| 酸度系数(pKa) | 13.42±0.46(Predicted) |
DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险等级 | IRRITANT |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 50mg | 660元 |
| 2024/04/30 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 10mM * 1mLin DMSO | 726元 |