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| | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Basic information |
| Product Name: | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE | | Synonyms: | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE;CHEMBRDG-BB 9070724;2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide;Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-;Brn 2857211;N-(Dimethoxy-3,4 benzyl)-chloroacetamide;N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french];2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE) | | CAS: | 65836-72-8 | | MF: | C11H14ClNO3 | | MW: | 243.69 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 65836-72-8.mol |  |
| | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Chemical Properties |
| Melting point | 116-118 °C(Solv: carbon tetrachloride (56-23-5)) | | Boiling point | 425.7±45.0 °C(Predicted) | | density | 1.194±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 150 mg/mL (615.54 mM) | | pka | 13.42±0.46(Predicted) |
| Hazard Codes | Xi | | HazardClass | IRRITANT |
| | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Usage And Synthesis |
| Biological Activity | DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM. | | in vitro | Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively. | | in vivo | DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity. | | target | IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells) |
| | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Preparation Products And Raw materials |
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