ChemicalBook >> CAS DataBase List >>2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- CAS No.
- 65836-72-8
- Chemical Name:
- 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- Synonyms
- DKM 2-93;Brn 2857211;CHEMBRDG-BB 9070724;N-(Dimethoxy-3,4 benzyl)-chloroacetamide;2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE;N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french];2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide;2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide;Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-;2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
- CBNumber:
- CB9796621
- Molecular Formula:
- C11H14ClNO3
- Molecular Weight:
- 243.69
- MDL Number:
- MFCD01733639
- MOL File:
- 65836-72-8.mol
Last updated:2023-05-21 10:59:17
| Melting point | 116-118 °C(Solv: carbon tetrachloride (56-23-5)) |
|---|---|
| Boiling point | 425.7±45.0 °C(Predicted) |
| Density | 1.194±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 150 mg/mL (615.54 mM) |
| pka | 13.42±0.46(Predicted) |
| EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H311-H331-H341 |
| Precautionary statements | P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501 |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6514 | DKM2-93 98.76% | 65836-72-8 | 100mg | $84 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC114033 | 2-Chloro-N-(3,4-dimethoxybenzyl)acetamide | 65836-72-8 | 250mg | $85 | 2021-12-16 | Buy |
| Matrix Scientific | 029584 | 2-Chloro-N-(3,4-dimethoxybenzyl)acetamide | 65836-72-8 | 500mg | $95 | 2021-12-16 | Buy |
| ChemScene | CS-6514 | DKM2-93 98.76% | 65836-72-8 | 200mg | $144 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC114033 | 2-Chloro-N-(3,4-dimethoxybenzyl)acetamide | 65836-72-8 | 500mg | $150 | 2021-12-16 | Buy |
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Chemical Properties,Uses,Production
Biological Activity
DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM.
in vitro
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
in vivo
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
target
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 62)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4874 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
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1of4
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
CHEMBRDG-BB 9070724
2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide
Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-
Brn 2857211
N-(Dimethoxy-3,4 benzyl)-chloroacetamide
N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]
2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide
DKM 2-93
E1 activating enzyme,Ubiquitin activating enzyme,E1/E2/E3 Enzyme,Inhibitor,DKM 2-93,Ubiquitin conjugating enzyme,Ubiquitin ligase,inhibit,E3 ligating enzyme,E2 conjugating enzyme,DKM 293,DKM 2 93
65836-72-8