[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

68341-09-3

CAS-Nr.: 68341-09-3

Englisch Name:: [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

Synonyma:: CUAM;Cu-ASTM;Cu-ATSM;CuII(atsm);Cu-ASTM >=98% (HPLC);Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II);[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

CBNumber:: CB32750504

Summenformel:: C8H14CuN6S2

Molgewicht:: 321.91296

MOL-Datei:: 68341-09-3.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 24

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Eigenschaften

storage temp.: 2-8°C

Löslichkeit: DMSO: soluble10mg/mL, clear

Aggregatzustand: powder

Farbe: brown to dark red-brown

Sicherheit

WGK Germany	3

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Cu-ATSM is preclinically used as a potential therapy for ALS (amyotrophic lateral sclerosis). A potential anti-Alzheimer''s agent.

Biochem/physiol Actions

Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. CuII(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 24)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21688	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
YangZhou Ruihong Biotech Co., Ltd.	015380367604 15380367604		China	509	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3501	55
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Taizhou Nanfeng Pharmaceutical Research Institute	3821987872	nanfengdrug@163.com	China	15323	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
Cu-ASTM
CuII(atsm)
Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)
CUAM
Cu-ATSM
Cu-ASTM >=98% (HPLC)
68341-09-3