Novobiocin
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- CAS-Nr.
- 303-81-1
- Bezeichnung:
- Novobiocin
- Englisch Name:
- Novobiocin
- Synonyma:
- inamycin;pa93;U 6391;novo-r;C05080;albamix;cathocin;robiocina;NOVOBIOCIN;cathomycin
- CBNumber:
- CB4500553
- Summenformel:
- C31H36N2O11
- Molgewicht:
- 612.62
- MOL-Datei:
- 303-81-1.mol
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Novobiocin Eigenschaften
- Schmelzpunkt:
- 170-172 °C
- alpha
- D24 -63.0° (c = 1 in ethanol)
- Siedepunkt:
- 657.29°C (rough estimate)
- Dichte
- 1.3448
- Brechungsindex
- 1.5800 (estimate)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- pKa1 4.3; pKa2 9.1(at 25℃)
- Farbe
- White to Pale Yellow
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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Novobiocin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
A light-yellow to white antibiotic produced by Streptomyces niveus. Available as calcium
and sodium salts.
Verwenden
Novobiocin is an aminocoumarin antibiotic isolated from a number of species of Streptomyces. Novobiocin exhibits broad spectrum Gram positive activity and was used clinically. Novobiocin is a potent inhibitor of bacterial DNA gyrase and a competitive inhibitor of the ATPase reaction catalysed by GyrB.
Definition
ChEBI: A coumarin-derived antibiotic obtained from Streptomyces niveus.
Weltgesundheitsorganisation (WHO)
Novobiocin, an antibiotic with a narrow spectrum of activity, was
introduced in 1956. Its use was subsequently associated with serious adverse
effects including blood dyscrasias. In view of its toxicity there are no current valid
indications for its use. Although preparations containing novobiocin may remain
available in some countries it has largely lapsed into disuse.
Hazard
May have damaging side effects.
Novobiocin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Novobiocin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 83)Lieferanten
303-81-1(Novobiocin)Verwandte Suche:
- NOVOBIOCIN
- cathocin
- cathomycin
- crystallinicacid
- -hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-oxo-2h-1-benzopyran-3-yl)-4-hydroxy-
- novo-r
- pa93
- U 6391
- 3-(3-methyl-2-butenyl)-
- albamix
- antibioticpa-93
- benzamide,n-(7-((3-o-(aminocarbonyl)-6-deoxy-5-c-methyl-4-o-methyl-beta-l-lyxo
- cardelmycin
- robiocina
- sirbiocina
- spheromycin
- stilbiocina
- NOVOBIOCIN (200 MG)H0D3271012UG/MG(DR)
- NOVOBIOCIN, USP STANDARD
- 7-[4'-(Carbamoyloxy)-tetrahydro-3'-hydroxy-5'-methoxy-6',6'-dimethylpyran-2'-yloxy]-4-hydroxy-3-[4''-hydroxy (3''-methyl-2''-butenyl)-benzamide]-8-methylcoumarin
- C05080
- Novobiocin (200 mg)
- AlbaMycin, VulcaMycin, PA 93, WS 6629, Griseoflavin, S 800.
- Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-
- Novobiocin powder
- Novobiocin USP/EP/BP
- (3R,4S,5R,6R)-5-Hydroxy-6-((4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido)-8-methyl-2-oxo-2H-chromen-7-yl)oxy)-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate
- Novobiocin (1475008)
- inamycin
- 303-81-1
