Fludrocortison-21-acetat
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- CAS-Nr.
- 514-36-3
- Bezeichnung:
- Fludrocortison-21-acetat
- Englisch Name:
- Fludrocortisone acetate
- Synonyma:
- 9α;U 4845;NSC 15186;cortineff;scherofluron;alfloroneacetate;Fluorocortisol acetate;FLUDROCORTISONE ACETATE;9-FLUOROCORTISOL ACETATE;9α-Fluorcortisol acetate
- CBNumber:
- CB5442481
- Summenformel:
- C23H31FO6
- Molgewicht:
- 422.49
- MOL-Datei:
- 514-36-3.mol
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Fludrocortison-21-acetat Eigenschaften
- Schmelzpunkt:
- 233-234°C
- Siedepunkt:
- 575.1±50.0 °C(Predicted)
- alpha
- D23 +123° (c = 0.64 in chloroform)
- Dichte
- 1.0953 (rough estimate)
- Brechungsindex
- 1.5980 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- Practically insoluble in water, sparingly soluble in anhydrous ethanol.
- pka
- 12.06±0.70(Predicted)
- Farbe
- White to Off-White
- Wasserlöslichkeit
- 54mg/L(25 ºC)
- InChIKey
- UUHYILPJUKGJDI-XYNXPQAZSA-N
- SMILES
- F[C@]12[C@H](C[C@@]3([C@@](O)(C(=O)COC(=O)C)CC[C@@]3([H])[C@]1([H])CCC1=CC(=O)CC[C@]21C)C)O |&1:1,2,4,5,16,18,28,r|
- CAS Datenbank
- 514-36-3(CAS DataBase Reference)
- EPA chemische Informationen
- Fluorocortisone acetate (514-36-3)
Fludrocortison-21-acetat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Fludrocortisone acetate is the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist. Fludrocortisone acetate (0.1-5 μg/animal) promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 μg/animal. Formulations containing fludrocortisone acetate have been used in the treatment of Addison’s disease.
Chemische Eigenschaften
Crystalline Solid
Definition
ChEBI: An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid acti
ns are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia.
Allgemeine Beschreibung
Fludrocortisone acetate,21-acetyloxy-9-fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione, 9α-fluorohydrocortisone (Florinef Acetate), isused only for the treatment of Addison disease and for inhibitionof endogenous adrenocortical secretions. It has up to about 800 times the MC activity of hydrocortisone and about 11 times the GC activity. Its potent activity stimulated the synthesis and study of the many fluorinated steroids. Although its great salt-retaining activity limits its use to Addison disease, it has sufficient GC activity that in some cases of the disease, additional GCs need not be prescribed.
Fludrocortison-21-acetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fludrocortison-21-acetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 220)Lieferanten
514-36-3(Fludrocortison-21-acetat)Verwandte Suche:
- 17-dihydroxy-20-dion(11-beta)-pregn-4-ene-21-(acetyloxy)-9-fluoro-11
- 20-dione,9-fluoro-11-beta,17,21-trihydroxy-pregn-4-ene-21-acetate
- 9-alpha-fluorohydrocortisone-21-acetate
- 9-alpha-fluorohydrocortisoneacetate
- 9-fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione21-acetate
- 9-fluoro-17-hydroxy-corticosteron21-acetate
- FLUDROCORTISONEACETATE,MICRONIZED,USP
- 9α-Fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
- 9α-Fluorocortisol 21-acetate
- 9α-Fluorohydrocortisone 21-acetate
- Corticosterone, 9-fluoro-17-hydroxy-, 21-acetate (6CI)
- Fluorocortisol acetate
- Fluorohydrocortisone acetate
- NSC 15186
- Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-
- Pregn-4-ene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-acetate (7CI, 8CI)
- U 4845
- (11)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione
- 9a-Fluorocortisol 21-acetate
- Fludrocortisone acetate Solution, 100ppm
- Fludrocortisone Acetate (200 mg)
- Fludrocortisone 21- acetate solution,100ppm
- 21-(Acetyloxy)-9-fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione
- Fludrocortisone Acetate (250 mg)
- Fludrocortisone Acetate, Micronized
- 9-Fluorocortisol acetate, 9-Fluorohydrocortisone acetate, 9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate
- Fludrocortisone Acetate Solution
- alfloroneacetate
- cortineff
- fludrocortisone21-acetate
- scherofluron
- FLUDROCORTISONE ACETATE
- 9-FLUOROCORTISOL ACETATE
- 9-FLUOROHYDROCORTISONE ACETATE
- 9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE ACETATE
- 4-PREGNENE-9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIOL-3,20-DIONE ACETATE
- 4-PREGNEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE ACETATE
- [2-[(9s)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
- FLUDROCORTISONE ACETATE ASSAY STANDARD BP(CRM STANDARD)
- 9α-fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate
- Fludrocortisone acetate CRS
- Fludrocortisone Acetate RS
- 9α-Fludrocortisone acetate
- 9α-Fluorcortisol acetate
- Fludrocortison-21-acetat
- 2-((8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
- Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-,(11b)-
- Fludrocortisone acetate USP/EP/BP
- 9α-Fludrocortisone acetate
- 9α-Fluorcortisol acetate
- 9α-fluorocortisol acetate
- Fludrocortisone Acetate (1273003)
- 4-PREGNEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE-21-ACETATE
- Fludrocortisone acetate(9α-Fluorocortisone acetate)
- 9α
- 514-36-3
- C23H31FO6
- BioChemical
