Cortison Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Off-White Crystalline Powder
Verwenden
Cortisone is used for inflammatory processes, allergies, and adrenal insufficiency.
Definition
ChEBI: A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.
Allgemeine Beschreibung
Cortisone is a corticosteroid produced in the adrenal glands. Cortisone is administered for short term pain relief and to reduce swelling from inflammation. This Certified Spiking Solution
? is applicable in LC-MS/MS applications for endocrinology, clinical chemistry and neonatal screening.
Hazard
Damaging side effects, e.g., sodium retention from ingestion.
Pharmakokinetik
Following oral administration, cortisone acetate and hydrocortisone acetate are completely and
rapidly deacetylated by first-pass metabolism. Much of the oral cortisone, however, is inactivated by
oxidative metabolism before it can be converted to hydrocortisone in the liver. The pharmacokinetics
for hydrocortisone acetate is indistinguishable from that of orally administered hydrocortisone. Oral
hydrocortisone is completely absorbed, with a bioavailability of greater than 95% and a half-life of 1 to 2 hours
(23).
Clinical Use
Cortisone is administered orally or by intramuscular (IM) injection as its 21-acetate (cortisone acetate).Cortisone acetate or hydrocortisone usually is the corticosteroid of choice for replacement therapy in patients
with adrenocortical insufficiency, because these drugs have both glucocorticoid and mineralocorticoid
properties.
Stoffwechsel
The metabolism of hydrocortisone has been previously described. Cortisone acetate is slowly
absorbed from IM injection sites over a period of 24 to 48 hours and is reserved for patients who are unable to
take the drug orally. The acetate ester derivative demonstrates increased stability and has a longer duration of
action when administered by IM injection. Thus, smaller doses can be used. Similarly, hydrocortisone may be
dispensed as its 21-acetate (hydrocortisone acetate), which is superior to cortisone acetate when injected
intra-articularly.
läuterung methode
Crystallise cortisone from 95% EtOH or acetone. The UV has 14,000 M-1cm -1 at 237nm (EtOH). [Beilstein 8 IV 3480, Hems J Pharm Pharmacol 5 409 1953, Beilstein 8 IV 3480.]
Cortison Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
