8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
- CAS No.
- 93882-12-3
- Chemical Name:
- 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
- Synonyms
- pcpt-camp;8-CPT-CAMP, NA;8-PCPT-CAMP NA;CAMP, 8-PCPT-, NA;8-CPT-cAMP sodium;8-(p-Chlorophenylthio;8-CPT-CAMP SODIUM SALT;8-CPT-Cyclic AMP (sodium salt);8-(4-CHLOROPHENYLTHIO)-CAMP SODIUM;8-(4-CHLOROPHENYLTHIO)ADENOSINE 3':5'-CY CLIC MONOP
- CBNumber:
- CB1676640
- Molecular Formula:
- C16H14ClN5NaO6PS
- Molecular Weight:
- 493.79
- MDL Number:
- MFCD00057683
- MOL File:
- 93882-12-3.mol
- MSDS File:
- SDS
8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C3912 | 8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt ≥97.0% (HPLC), powder | 93882-12-3 | 10mg | $92.2 | 2024-03-01 | Buy |
Sigma-Aldrich | 116812 | Adenosine 3?,5?-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt | 93882-12-3 | 10mg | $82.8 | 2024-03-01 | Buy |
Cayman Chemical | 12011 | 8-CPT-Cyclic AMP (sodium salt) ≥98% | 93882-12-3 | 10mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 12011 | 8-CPT-Cyclic AMP (sodium salt) ≥98% | 93882-12-3 | 25mg | $105 | 2024-03-01 | Buy |
Sigma-Aldrich | C3912 | 8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt ≥97.0% (HPLC), powder | 93882-12-3 | 50mg | $268 | 2024-03-01 | Buy |
8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Chemical Properties,Uses,Production
Uses
8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt has been used:
- to upregulate cellular cholesterol pump (adenosine triphosphate- (ATP-) binding cassette (ABC) transporter-1, ABCA-1)
- in glucose production assay
- to stimulate cystic fibrosis transmembrane conductance regulator (CFTR) channel in airway epithelia
Uses
8-CPT-cAMP is an efficient activator of cGK and cAMP-PK, and inhibitor of PDE.
General Description
Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50 = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50 = 25 μM).
Biological Activity
ka : 0.05 and 0.11 μm for pka and pkg, respectively8-cpt-cyclic amp is a lipophilic activator of the cyclic-amp- and cyclic-gmp-dependent protein kinases, pka and pkg.the ability of cgmp-dependent protein kinases (cgks) to activate camp response element (cre)-dependent gene transcription was compared with that of camp-dependent protein kinases (caks).
Biochem/physiol Actions
Cell permeable: yes
in vitro
a previous study found that 8-cpt-cyclic amp was a potent activator of camp-pk and cyclic-gmp-dependent protein kinase (cgmp-pk) both as purified enzymes and in platelet membranes. 8-cpt-cyclic amp was hydrolysed to a significant extent by the ca2+/calmodulin-dependent phosphodiesterase and by the cgmp-inhibited phosphodiesterase. moreover, sp-5,6- dcl-cbimps was also more effective than 8-cpt-cyclic amp in inducing quantitative phosphorylation of vasodilator-stimulated phosphoprotein in intact platelets [1]. another study indicated that 8-cpt-cyclic amp was a potent inhibitor of the cyclic gmp-specific phosphodiesterase (pde va). indeed, 8-cpt-cyclic amp could inhibit pde va with a potency similar to that of zaprinast. in addition, 8-cpt-cyclic amp was metabolized by pde va at a rate half that of cyclic gmp. the cyclic gmp-inhibited phosphodiesterase and the cyclic amp-specific phosphodiesterase could be inhibited by 8-cpt-cyclic amp as well [2].
References
[1] sandberg, m. ,butt, e.,nolte, c., et al. characterization of sp-5,6-dichloro-1-β-d-ribofuranosylbenzimidazole-3',5'-monophosphorothioate (sp-5,6-dcl-cbimps) as a potent and specific activator of cyclic-amp-dependent protein kinase in cell extracts and intact cells. biochemistry journal 279, 521-527 (1991).
[2] connolly, b. j.,willits, p.b.,warrington, b.h., et al. 8-(4-chlorophenyl)thio-cyclic amp is a potent inhibitor of the cyclic gmp-specific phosphodiesterase (pde va). biochemical pharmacology 44(12), 2303-2306 (1992).
8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Suppliers
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BOC Sciences | 16314854226 | inquiry@bocsci.com | United States | 9713 | 58 |
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