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ZK118182 isopropyl ester

ZK118182 isopropyl ester structure

CAS No.: 154927-31-8

Chemical Name:: ZK118182 isopropyl ester

Synonyms: ZK118182 isopropyl ester;QLJUNFBXIBNQOL-LMJZMJOFSA-N;ZK118182 isopropyl ester Exclusive;ZK118182 isopropyl ester,ZK-118182 isopropyl ester;propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate;Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI)

CBNumber:: CB22592893

Molecular Formula:: C23H37ClO5

Molecular Weight:: 428.99

MDL Number:: MFCD00929952

MOL File:: 154927-31-8.mol

Last updated:2023-07-12 17:07:11

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ZK118182 isopropyl ester Properties

Boiling point	553.1±50.0 °C(Predicted)
Density	1.14±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka	14.22±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H319-H336

Precautionary statements

P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501

NFPA 704

	3
2		0

ZK118182 isopropyl ester price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	13673	ZK118182 isopropyl ester ≥98%	154927-31-8	100μg	$208	2024-03-01	Buy
Cayman Chemical	13673	ZK118182 isopropyl ester ≥98%	154927-31-8	500μg	$925	2024-03-01	Buy
TRC	Z485905	ZK118182isopropylester	154927-31-8	250μg	$450	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0068932	((4-(5R-CHLORO-2Z-(3R-CYCLOHEXYL-3S-HYDROXY-1R-PROPENYL)-3S-HYDROXYCYCLOPENTYL)-2R-BUTENYL)OXY)-ACETIC ACID-1E-METHYLETHYL ESTER 95.00%	154927-31-8	5MG	$499.16	2021-12-16	Buy

Product number	Packaging	Price	Buy
13673	100μg	$208	Buy
13673	500μg	$925	Buy
Z485905	250μg	$450	Buy
HCH0068932	5MG	$499.16	Buy

ZK118182 isopropyl ester Chemical Properties,Uses,Production

Description

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF_2α and PGD₂, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC₅₀ = 16.5 nM) and a high nanomolar affinity for the DP receptor (K_i = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.

ZK118182 isopropyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

ZK118182 isopropyl ester Suppliers

Global( 18)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1991	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44894	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24023	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
BOC Sciences	65
Shanghai Hongye Biotechnology Co. Ltd	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	58
Energy Chemical	58
MedBioPharmaceutical Technology Inc	58
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58

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ZK118182 isopropyl ester Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI) propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate ZK118182 isopropyl ester Exclusive QLJUNFBXIBNQOL-LMJZMJOFSA-N ZK118182 isopropyl ester,ZK-118182 isopropyl ester 154927-31-8 C23H37ClO5