ZK118182 isopropyl ester
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- $208 - $925
- Product name: ZK118182 isopropyl ester
- CAS: 154927-31-8
- MF: C23H37ClO5
- MW: 428.99
- EINECS:
- MDL Number:MFCD00929952
- Synonyms:ZK118182 isopropyl ester;Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI);propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate;ZK118182 isopropyl ester Exclusive;QLJUNFBXIBNQOL-LMJZMJOFSA-N;ZK118182 isopropyl ester,ZK-118182 isopropyl ester
4 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Cayman Chemical
- TRC
Package
- 100μg
- 250μg
- 500μg
- 5MG
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0068932
- Product description((4-(5R-CHLORO-2Z-(3R-CYCLOHEXYL-3S-HYDROXY-1R-PROPENYL)-3S-HYDROXYCYCLOPENTYL)-2R-BUTENYL)OXY)-ACETIC ACID-1E-METHYLETHYL ESTER 95.00%
- Packaging5MG
- Price$499.16
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13673
- Product descriptionZK118182 isopropyl ester ≥98%
- Packaging100μg
- Price$208
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13673
- Product descriptionZK118182 isopropyl ester ≥98%
- Packaging500μg
- Price$925
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberZ485905
- Product descriptionZK118182isopropylester
- Packaging250μg
- Price$450
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | HCH0068932 | ((4-(5R-CHLORO-2Z-(3R-CYCLOHEXYL-3S-HYDROXY-1R-PROPENYL)-3S-HYDROXYCYCLOPENTYL)-2R-BUTENYL)OXY)-ACETIC ACID-1E-METHYLETHYL ESTER 95.00% | 5MG | $499.16 | 2021-12-16 | Buy |
| Cayman Chemical | 13673 | ZK118182 isopropyl ester ≥98% | 100μg | $208 | 2024-03-01 | Buy |
| Cayman Chemical | 13673 | ZK118182 isopropyl ester ≥98% | 500μg | $925 | 2024-03-01 | Buy |
| TRC | Z485905 | ZK118182isopropylester | 250μg | $450 | 2021-12-16 | Buy |
Properties
Boiling point :553.1±50.0 °C(Predicted)
Density :1.14±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka :14.22±0.70(Predicted)
Density :1.14±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka :14.22±0.70(Predicted)
Safety Information
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Description
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.More related product prices
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