7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
- CAS No.
- 18000-24-3
- Chemical Name:
- 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
- Synonyms
- 7-CKA;7-CL-KYNA;7-CHLOROKYNURENIC ACID;7-Chloroquinurenic acid;Kynurenic Acid Impurity 1;7-Chlorokynurenic acid (7-CKA);7-CHLOROKYNURENIC ACID HYDROCHLORIDE;7-Chloro-4-hydroxy-2-quinolinecarboxylic acid;7-chloro-4-oxo-1H-quinoline-2-carboxylic acid;7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
- CBNumber:
- CB4263777
- Molecular Formula:
- C10H6ClNO3
- Molecular Weight:
- 223.61
- MDL Number:
- MFCD00069227
- MOL File:
- 18000-24-3.mol
- MSDS File:
- SDS
| Melting point | 277-278 °C (decomp) |
|---|---|
| Boiling point | 461.5±45.0 °C(Predicted) |
| Density | 1.600±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 0.1 M NaOH: 13.7 mg/mL |
| form | solid |
| pka | 0.90±0.30(Predicted) |
| color | tan |
| CAS DataBase Reference | 18000-24-3(CAS DataBase Reference) |
| FDA UNII | S7936QON2K |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J61359 | 7-Chlorokynurenic acid, 99+% | 18000-24-3 | 10mg | $174.65 | 2024-03-01 | Buy |
| Alfa Aesar | J61359 | 7-Chlorokynurenic acid, 99+% | 18000-24-3 | 50mg | $327.65 | 2024-03-01 | Buy |
| Tocris | 0237 | 7-Chlorokynurenicacid ≥98%(HPLC) | 18000-24-3 | 50 | $360 | 2021-12-16 | Buy |
| Tocris | 0237 | 7-Chlorokynurenicacid ≥98%(HPLC) | 18000-24-3 | 10 | $86 | 2021-12-16 | Buy |
| TRC | C366958 | 7-Chlorokynurenicacid | 18000-24-3 | 25mg | $160 | 2021-12-16 | Buy |
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Chemical Properties,Uses,Production
Target
Ki: 0.59 μM (reuptake of glutamate) IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)
Uses
NMDA receptor antagonist at the glycine site
Definition
ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Biological Functions
Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.
Biological Activity
NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
in vivo
Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
storage
Room temperature
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Preparation Products And Raw materials
Raw materials
Preparation Products
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9911 | 50 |