6-Shogaol
- CAS No.
- 555-66-8
- Chemical Name:
- 6-Shogaol
- Synonyms
- SHOGAOL;6-SHOGAOL;6-Shagaol;SHOGAOL, 6-;6-gingerenol;6-Shogaol USP/EP/BP;[6]-Shogaol D5 (Major);TIANFU-CHEM - 6-Shogaol;1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one;1-(4-Hydroxy-3-methoxyphenyl)dec-4-en-3-one
- CBNumber:
- CB4748322
- Molecular Formula:
- C17H24O3
- Molecular Weight:
- 276.37
- MDL Number:
- MFCD01736094
- MOL File:
- 555-66-8.mol
| Boiling point | 427.5±35.0 °C(Predicted) |
|---|---|
| Density | 1.0448 g/cm3(Temp: 25 °C) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 10.01±0.20(Predicted) |
| color | Colourless to Light Yellow |
| BRN | 2056098 |
| InChI | InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3 |
| InChIKey | OQWKEEOHDMUXEO-BQYQJAHWSA-N |
| SMILES | C(C1=CC=C(O)C(OC)=C1)CC(=O)C=CCCCCC |
| LogP | 3.789 (est) |
| CAS DataBase Reference | 555-66-8(CAS DataBase Reference) |
| FDA UNII | 83DNB5FIRF |
| NIST Chemistry Reference | 6-shogaol(555-66-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
6-Shogaol price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00311 | [6]-Shogaol ≥90% (HPLC) | 555-66-8 | 50mg | $947 | 2024-03-01 | Buy |
| Sigma-Aldrich | 39303 | [6]-Shogaol analytical standard | 555-66-8 | 10mg | $740 | 2024-03-01 | Buy |
| Cayman Chemical | 11901 | 6-Shogaol ≥95% | 555-66-8 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 11901 | 6-Shogaol ≥95% | 555-66-8 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 11901 | 6-Shogaol ≥95% | 555-66-8 | 10mg | $321 | 2024-03-01 | Buy |
6-Shogaol Chemical Properties,Uses,Production
Uses
[6]-Shogaol is an aromatic constituent of ginger and the chain-dehydroxylated analog of [6]-Gingerol. [6]-Shogaol has activity very similar to [6]-Gingerol and produced an inhibition of spontaneous motor activity, antipyretic and analgesic effects, and prolonged hexobarbital-induced sleeping time. [6]-Shogaol also has potent antitussive activity and affected the cortical EEG.
Definition
ChEBI: [6]-Shogaol is a monomethoxybenzene, a member of phenols and an enone.
Anticancer Research
6-Shogaol is the dehydrated product of 6-gingerol, extracted from the rhizome ofginger. Treatment of HCC cell line with 6-shogaol resulted in cells with apoptoticphenotypes, which showed signs of cell and nuclear shrinkage as well as substantialchromatin condensation. De-phosphorylation of PERK and activation of theexpression of CHOP initiate caspase cascade reaction inducing apoptosis inHCC. Two-dimensional gel electrophoretic analysis of proteome revealed that in response to the treatment with 6-shogaol, a significant stimulation was observed inproteins related to the ER stress, signifying that apoptosis induced by 6-shogoal didinvolve ER stress. Cells showed marked rise in the UPR target expression, HSP70,Grp94, Grp78/Bip and the other ER chaperones on exposure to 6-shogoal in a time-dependentmanner, which elicited activation of caspase-3 and degradation of polyADP ribose polymerase (PARP). Various ER chaperone proteins improve adaptationof cancer cells to hypoxic environment and aid in developing resistance againstanticancer therapy (Zorzi and Bonvini 2011; Urra et al. 2016). Screening of specificinhibitors of Grp78 as antitumour agents (Hu et al. 2012; Liu et al. 2013; Venkatesanet al. 2015) implies that inhibition of Grp78/Bip is a very promising anticancerstrategy. HCC cells are selectively killed by 6-shogaol in the absence of anynoticeable toxic consequence on normal healthy cells and very little toxicity asstudied on SMMC7721 xenograft mice. Administration of 6-shogaol and salubrinaltogether for distinct time intervals resulted in significant increase in ER stress in thecell. It appears that 6-shogaol in combination with salubrinal has great therapeuticvalue against various malignancies including HCC (Hu et al. 2012).
6-Shogaol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from 6-Shogaol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-28 | 6-Shogaol
555-66-8
|
US $0.00 / kg | 25kg | 1%（Water Soluble） 5% | Inquiry | PNP Biotech Co. Ltd | |
 |
2023-10-16 | 3-Isothioureidopropionic acid
555-66-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | 6-Shogaol
555-66-8
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- 6-Shogaol
555-66-8
- US $0.00 / kg
- 1%（Water Soluble） 5%
- PNP Biotech Co. Ltd
-
- 3-Isothioureidopropionic acid
555-66-8
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 6-Shogaol
555-66-8
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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