ChemicalBook >> CAS DataBase List >>NBQX DISODIUM SALT
NBQX DISODIUM SALT
- CAS No.
- 118876-58-7
- Chemical Name:
- NBQX DISODIUM SALT
- Synonyms
- NBQX;FG 9202;NBQX NEW;NBQX HYDRATE;NBQX DISODIUM;FG 9202 DISODIUM;Dihydroxyquinone;NBQX DISODIUM SALT;FG9202;FG-9202;FG 9202;NBQX disodium salt hydrate
- CBNumber:
- CB5274224
- Molecular Formula:
- C12H8N4O6S
- Molecular Weight:
- 336.28
- MDL Number:
- MFCD00274065
- MOL File:
- 118876-58-7.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | 361°C |
|---|---|
| Density | 1.6027 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | methanol: 0.25 mg/mL |
| form | solid |
| pka | 7.55±0.20(Predicted) |
| color | yellow |
| Stability | Freezer at -20°C |
| InChIKey | UQNAFPHGVPVTAL-UHFFFAOYSA-N |
| FDA UNII | 8LZ6Q43V2S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
NBQX DISODIUM SALT price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N171 | NBQX hydrate powder, ≥98% (HPLC) | 118876-58-7 | 5mg | $270 | 2024-03-01 | Buy |
| Sigma-Aldrich | N171 | NBQX hydrate powder, ≥98% (HPLC) | 118876-58-7 | 25mg | $444 | 2024-03-01 | Buy |
| Sigma-Aldrich | N183 | NBQX disodium salt hydrate ≥98% (HPLC), lyophilized solid | 118876-58-7 | 5mg | $320 | 2024-03-01 | Buy |
| Sigma-Aldrich | N183 | NBQX disodium salt hydrate ≥98% (HPLC), lyophilized solid | 118876-58-7 | 25mg | $1290 | 2024-03-01 | Buy |
| Tocris | 0373 | NBQX ≥98%(HPLC) | 118876-58-7 | 50 | $910 | 2021-12-16 | Buy |
NBQX DISODIUM SALT Chemical Properties,Uses,Production
Chemical Properties
Yellow Crystalline Solid
Uses
A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.
Uses
NBQX disodium salt hydrate has been used:
- in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
- as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
- in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)
Definition
ChEBI: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative.
General Description
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor.
Biological Activity
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset™ .
Biochem/physiol Actions
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear.
storage
Room temperature
NBQX DISODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 115)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2971 | 58 |
118876-58-7(NBQX DISODIUM SALT)Related Search:
DNQX
CNQX
(RS)-AMPA
1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE
1,8-Dihydroxyanthraquinone
NBQX DISODIUM SALT
6-NITROQUINOXALINE-2,3-DIONE
4-Nitro-1-naphthylamine
6-NITRO-1,2,3,4-TETRAHYDRO QUINOXALINE
7-NITRO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE
1of4
NBQX
2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline
FG 9202, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate
FG 9202 hydrate disodium salt, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate disodium salt
NBQX hydrate disodium salt
2,3-Doxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
FG 9202 disodium salt hydrate
2,3-Dihydroxy-6-nitrobenzo[f]quinoxaline-7-sulfonamide
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3(1H,4H)-dione
1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate
NBQX disodium salt hydrate
6-Nitro-2,3-dioxo-2,3-dihydrobenzo[f]quinoxaline-7-sulfonamide
NBQX DISODIUM
NBQX DISODIUM SALT
1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALINE-2,3-DIONE
6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALINE-2,3-DIONE, DISODIUM SALT
6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2,3-DIONE
6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2,3-DIONE 2NA
1,2,3,4-TETRAHYDRO-6-NITRO-2,3-DIOXO-BENZO[F]QUINOXALINE-7-SULFONAMIDE
1,2,3,4-TETRAHYDRO-6-NITRO-2,3-DIOXO-BENZO[F]QUINOXALINE-7-SULFONAMIDE DISODIUM
2,3-DIHYDROXY-6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE
2,3-DIHYDROXY-6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE 2NA
2,3-DIOXO-6-NITRO-1,2,3,4-TETRAHYDROBENZO[F]QUINOXALINE-7-SULFONAMIDE
2,3-DIOXO-6-NITRO-1,2,3,4-TETRAHYDROBENZO[F]QUINOXALINE-7-SULFONAMIDE DISODIUM SALT
FG 9202
FG 9202 DISODIUM
NBQX DISODIUM (FG 9202) NEUROPROTECTIVE GLUTA
NBQX HYDRATE
1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt
disodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate hydrate
FG9202;FG-9202;FG 9202
NBQX NEW
Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-
6-Nitro-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide
Dihydroxyquinone
118876-58-7
C12H6N4Na2O6S
C12H8N4O6S
C12H6N4O6SNa2
Ligand-Gated Ion Channels
Ionotropic Glutamate Receptor Modulators
Ion Channels
Cell Biology
Cell Signaling and Neuroscience
BioChemical
Glutamate
Glutamate receptor
Heterocyclic Compounds
Neurochemicals