ChemicalBook >> CAS DataBase List >>11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione structure

CAS No.: 13951-70-7

Chemical Name:: 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Synonyms: 16α-hydroxy-prednisolone;11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3;BNKY015-BD04

CBNumber:: CB7352308

Molecular Formula:: C21H28O6

Molecular Weight:: 376.44

MDL Number:: MFCD00872019

MOL File:: 13951-70-7.mol

MSDS File:: SDS

Last updated:2024-03-19 09:29:41

Request For Quotation

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Properties

Melting point	235-238°C
Boiling point	591.5±50.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	11.93±0.70(Predicted)
color	White to Light Yellow
Water Solubility	815mg/L at 20℃
LogP	0.8 at 25℃
CAS DataBase Reference	13951-70-7(CAS DataBase Reference)
FDA UNII	SW97540DC2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361
Precautionary statements	P201-P202-P281-P308+P313-P405-P501

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	27169	16α-hydroxy Prednisolone	13951-70-7	1g	$32	2024-03-01	Buy
Cayman Chemical	27169	16α-hydroxy Prednisolone	13951-70-7	25g	$479	2024-03-01	Buy
Cayman Chemical	27169	16α-hydroxy Prednisolone	13951-70-7	5g	$139	2024-03-01	Buy
Cayman Chemical	27169	16α-hydroxy Prednisolone	13951-70-7	10g	$243	2024-03-01	Buy
TRC	T296075	11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione	13951-70-7	500mg	$245	2021-12-16	Buy

Product number	Packaging	Price	Buy
27169	1g	$32	Buy
27169	25g	$479	Buy
27169	5g	$139	Buy
27169	10g	$243	Buy
T296075	500mg	$245	Buy

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties,Uses,Production

Related substances

Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties.

Chemical Properties

White Crystalline Solid

Uses

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.

Uses

A metabolite of Budesonide (B689490), an antiinflammatory agent.

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione synthesis

Synthesis of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione from 16alpha-Hydroxyprednisonlone acetate

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

112,21-dihydroxypregna-1,4,16-triene-3,20-dione 16alpha-Hydroxyprednisonlone acetate

Preparation Products

Desonide

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Suppliers

Global( 342)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15956	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58

Supplier	Advantage
BIONNA MEDICINE CO.,LTD	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Hubei XinRunde Chemical Co., Ltd.	55
career henan chemical co	58
Accela ChemBio Inc.	58

View Lastest Price from 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-10	11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione 13951-70-7	US $80.00-800.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2024-03-16	11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione 13951-70-7	US $0.00 / KG	100g	98%+	100kg	WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2023-11-27	16alpha-Hydroxyprednisolone 13951-70-7	US $0.00 / kg	1kg	99% HPLC	20 tons	Wuhan Senwayer Century Chemical Co.,Ltd

11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione
13951-70-7
US $80.00-800.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione
13951-70-7
US $0.00 / KG
98%+
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

16alpha-Hydroxyprednisolone
13951-70-7
US $0.00 / kg
99% HPLC
Wuhan Senwayer Century Chemical Co.,Ltd

13951-70-7(11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione)Related Search:

Budesonide Sulfate SodiuM (Mixture of DiastereoMers) 14,15-Dehydro Budesonide 9α-BroMobudesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) Desonide

Budesonide Di-Norbudesonide (Mixture of DiastereoMers) 9,11-Anhydrobudesonide Budesonide EP Impurity D (Mixture of Diastereomers) 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione

(16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione 1,2-Dehydrobudesonide Budesonide Impurity 1 (Mixture of Diastereomers) Budesonide EP Impurity A-d4 Flunisolide

(r)-budesonide 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Ciclesonide

1of4

16A-HYDROXY-PREDNISONLONE 11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16 Alpha Hydroxprednisolone 16α-HYDROXY-PREDNISONLONE 11,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione Einecs 237-731-1 16A-HYDROXY-PREDNISOLONE 11a,16b,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione 11B,16A,17A,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 16a-Hydroxypredisolone (11β,16α)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16α-Hydroxyprednisolon Budesonide IMpurity A (16-alpha-Hydroxy-Prednisolone) (8S,9S,10R,13S,14S,16R,17S)-11,16,17-Trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one Prednisolone impurity 1/Prednisolone EP Impurity A/16-alpha-Hydroxy-Prednisolone/11?,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 9-[3-(1,2-dihydroxyheptyl)-2-oxiranyl]-9-hydroxynonanoic acid Budesonide iMpurit A Budesonide EP Impurity A (16-alpha-Hydroxy-Prednisolone) BNKY015-BD04 Budesonide EP Impurity A 16b 20-dione 21-Tetrahydroxy-pregna-1 4-diene-3 Budesonide impurity A Budesonide Impurity 1(Budesonide EP Impurity A) 11beta,16alpha,17,21-Tetrahydroxypr Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)- Desonide Impurity A 16α-hydroxy Prednisolone 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione USP/EP/BP Tmo Trimethylamine N-Oxide Dihydrate Powder 16α-hydroxy-prednisonlone 16 α Hydroxy PrednisoloneQ: What is 16 α Hydroxy Prednisolone Q: What is the CAS Number of 16 α Hydroxy Prednisolone Q: What is the storage condition of 16 α Hydroxy Prednisolone 16α-Hydroxyprednisolone-d5 11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione(triamcinolone) 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16-ALPHA-HYDROXY PREDNISOLONE 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16α-hydroxy-prednisolone (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one 16α-Hydroeyprednisolone Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)- 16α-Hydroxyprednisolone (Budesonide Impurity) 11β,16α,17α,21-Tetrahydroxypregnα-1,4-diene-3,20-dione Desonide EP Impurity-A 11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione 11β,16α,17α,21-tetrahydroxyprogesterone-1,4-diene-3,20-dione (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one 13951-70-7 13952-70-7 Pharmaceutical Raw Materials Metabolites & Impurities Intermediates & Fine Chemicals Metabolites Pharmaceuticals Steroids