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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 구조식 이미지

카스 번호:: 13951-70-7

상품명:: 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

동의어(영문):: 16α-hydroxy-prednisolone;11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3;BNKY015-BD04

CBNumber:: CB7352308

분자식:: C21H28O6

포뮬러 무게:: 376.44

MOL 파일:: 13951-70-7.mol

속성

안전

용도

공급 업체 342

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 속성

녹는점: 235-238°C

끓는 점: 591.5±50.0 °C(Predicted)

밀도: 1.38±0.1 g/cm3(Predicted)

증기압: 0Pa at 25℃

저장 조건: Sealed in dry,2-8°C

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 11.93±0.70(Predicted)

색상: 흰색에서 밝은 노란색

수용성: 815mg/L at 20℃

LogP: 0.8 at 25℃

CAS 데이터베이스: 13951-70-7(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H361	태아 또는 생식능력에 손상을 일으킬 것으로 의심됨	생식독성 물질	구분 2	경고		P201, P202, P281, P308+P313, P405,P501

예방조치문구:

P201	사용 전 취급 설명서를 확보하시오.
P202	모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P281	요구되는 개인 보호구를 착용하시오
P308+P313	노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405	밀봉하여 저장하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione C화학적 특성, 용도, 생산

화학적 성질

White Crystalline Solid

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 준비 용품 및 원자재

원자재

112,21-dihydroxypregna-1,4,16-triene-3,20-dione 16alpha-Hydroxyprednisonlone acetate

준비 용품

Desonide

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 공급 업체

글로벌( 342)공급 업체

공급자	전화	이메일	국가	제품 수	이점
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15956	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 관련 검색:

프레드니손 프레드니솔원 9,11-Anhydrobudesonide Di-Norbudesonide (Mixture of DiastereoMers) Budesonide Sulfate SodiuM (Mixture of DiastereoMers) 14,15-Dehydro Budesonide 9α-BroMobudesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) Desonide Budesonide Budesonide EP Impurity D (Mixture of Diastereomers) 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione (16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione 1,2-Dehydrobudesonide Budesonide Impurity 1 (Mixture of Diastereomers) Budesonide EP Impurity A-d4 Flunisolide (r)-budesonide