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SNC 80

SNC 80 structure

CAS No.: 156727-74-1

Chemical Name:: SNC 80

Synonyms: SNC 80;NIH 10815;(+)-4-[(Ar)-alpha-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3;4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAM;(+)-4-[(aR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE;(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide;(+)-4-[(AR)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE;(+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

CBNumber:: CB7712786

Molecular Formula:: C28H39N3O2

Molecular Weight:: 449.63

MDL Number:: MFCD00672673

MOL File:: 156727-74-1.mol

Last updated:2023-09-04 15:51:00

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SNC 80 Properties

Melting point	122-123°C
Boiling point	564.8±50.0 °C(Predicted)
Density	1.040
storage temp.	Store at RT
solubility	DMSO: soluble
form	solid
pka	7.29±0.10(Predicted)
color	off-white
Stability	Store in Freezer
InChIKey	KQWVAUSXZDRQPZ-UMTXDNHDSA-N
SMILES	C(N(CC)CC)(=O)C1=CC=C([C@@H](N2C[C@@H](C)N(CC=C)C[C@@H]2C)C2=CC=CC(OC)=C2)C=C1
FDA UNII	L842QB22SW

SAFETY

Risk and Safety Statements

WGK Germany	3

SNC 80 price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S2812	SNC80 ≥98% (HPLC), solid	156727-74-1	5mg	$459	2024-03-01	Buy
Sigma-Aldrich	S2812	SNC80 ≥98% (HPLC), solid	156727-74-1	25mg	$1650	2024-03-01	Buy
Sigma-Aldrich	5.08161	SNC80 - CAS 156727-74-1 - Calbiochem	156727-74-1	10mg	$299	2024-03-01	Buy
Cayman Chemical	15599	SNC 80 ≥99%	156727-74-1	5mg	$68	2024-03-01	Buy
Cayman Chemical	15599	SNC 80 ≥99%	156727-74-1	25mg	$286	2024-03-01	Buy

Product number	Packaging	Price	Buy
S2812	5mg	$459	Buy
S2812	25mg	$1650	Buy
5.08161	10mg	$299	Buy
15599	5mg	$68	Buy
15599	25mg	$286	Buy

SNC 80 Chemical Properties,Uses,Production

Description

SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (K_i = 0.18 nM, IC₅₀ = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor. It effectively activates μ/δ receptor heteromers (EC₅₀ = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.

Chemical Properties

Crystalline Solid

Uses

Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.⁵

Uses

A highly selective and potent non-peptide -agonist, 2000-fold selective over u-receptors

Definition

ChEBI: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.

Biological Activity

A highly selective and potent non-peptide δ -opioid agonist, 2000-fold selective over μ -opioid receptors.

Biochem/physiol Actions

SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4

storage

Store at RT

SNC 80 synthesis

Synthesis of SNC 80 from N,N-diethyl-4-forMylbenzaMide and 3-METHOXYPHENYLMAGNESIUM BROMIDE and Piperazine, 2,5-dimethyl-1-(2-propenyl)-, (2R,5S)- (9CI)

SNC 80 Preparation Products And Raw materials

Raw materials

N,N-diethyl-4-forMylbenzaMide 4-(3-METHOXYBENZOYL)BENZOIC ACID rac-4-(3’-Methoxy-α-hydroxybenzyl)-N,N-diethylbenzamide RAC-4-(3'-METHOXY-A-CHLOROBENZYL)-N,N-DIETHYLBENZAMIDE 3-METHOXYPHENYLMAGNESIUM BROMIDE

4-(3'-METHOXYBENZOYL)-N,N-DIETHYLBENZAMIDE 3-METHOXY-4'-METHYLBENZOPHENONE Piperazine, 2,5-dimethyl-1-(2-propenyl)-, (2R,5S)- (9CI) 3-METHOXYBENZOYL CHLORIDE 4-Formylbenzoic acid

Toluene

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Preparation Products

SNC 80 Suppliers

Global( 80)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Amatek Scientific Co. Ltd.	0512-56316828	info@amateksci.com	China	28821	58

Supplier	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky（shanghai）International Co.,Ltd.	50
Sigma-Aldrich	80
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58
Amatek Scientific Co. Ltd.	58

SNC 80 Spectrum

SNC 80(156727-74-1)¹HNMR

156727-74-1(SNC 80)Related Search:

1-(4-METHYLBENZYL)PIPERAZINE 2-Aminoethyldiisopropylamine (R)-(-)-2-Methylpiperazine 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE 3-Methyl-1-benzyl-piperazine

trans-2,5-Dimethylpiperazine [4-[(4-METHYLPIPERAZIN-1-YL)METHYL]PHENYL]METHYLAMINE N-1-Benzyl-2-methylpiperazine N,N-DIETHYLBENZAMIDE (S)-1-ISOPROPYL-2-METHYL-PIPERAZINE

4-[(S)-[(2S,5R)-2,5-DIMETHYL-4-(2-PROPENYL)-1-PIPERAZINYL]PHENYLMETHYL]-N,N-DIETHYLBENZAMIDE (2S,5R)-1-BENZYL-2,5-DIMETHYLPIPERAZINE N-[4-(AMINOMETHYL)BENZYL]-N,N-DIETHYLAMINE SNC 80 1-(3-METHOXYBENZYL)PIPERAZINE

[(4-METHYLPHENYL)PHENYLMETHYL]PIPERAZINE Aligeron CHEMBRDG-BB 4015543

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(+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide 4-[(R)-[(2S,5R)-2,5-Dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide (+)-4-[(Ar)-alpha-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3 NIH 10815 (+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAM (+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE (+)-4-[(AR)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE SNC 80 (+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide (+)-4-[(aR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide Benzamide, 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl- 156727-74-1 C28H39N3O2 Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Chiral Reagents Opioid receptor and opioid-like receptor