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5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2

5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2 化学構造式
39024-57-2
CAS番号.
39024-57-2
化学名:
5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2
别名:
18-(5-オキソ-L-プロリン)-22-L-ロイシン-32-L-ロイシン-18-34-ガストリンI【ブタ】;5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2;(4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-カルバモイル-2-フェニルエチル]カルバモイル}-2-カルボキシエチル]カルバモイル}-3-メチルブチル]カルバモイル}-2-(1H-インドール-3-イル)エチル]カルバモイル}メチル)カルバモイル]-2-(4-ヒドロキシフェニル)エチル]カルバモイル}エチル]カルバモイル}-3-カルボキシプロピル]カルバモイル}-3-カルボキシプロピル]カルバモイル}-3-カルボキシプロピル]カルバモイル}-3-カルボキシプロピル]カルバモイル}-4-[(2S)-2-[(2S)-3-(1H-インドール-3-イル)-2-{[(2S)-1-(2-{[(2S)-5-オキソピロリジン-2-イル]ホルムアミド}アセチル)ピロリジン-2-イル]ホルムアミド}プロパンアミド]-4-メチルペンタンアミド]ブタン酸
英語名:
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
英語别名:
LHG-17;[Leu15]-HG-17;[LEU15]-GASTRIN I;gastrin I, human Leu15;(LEU15)-GASTRIN I (HUMAN);(Leu??)-Gastrin I (human);[Leucine15]-Little gastrin I;(Leu15)-Gastrin-17 I (human);[15-leucine]gastrin I, human;(15-LEUCINE) HUMAN GASTRIN I
CBNumber:
CB4485427
化学式:
C98H126N20O31
分子量:
2080.2
MOL File:
39024-57-2.mol

5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2 物理性質

沸点 :
2368.8±65.0 °C(Predicted)
比重(密度) :
1.400±0.06 g/cm3(Predicted)
貯蔵温度 :
−20°C
酸解離定数(Pka):
4.20±0.10(Predicted)
BRN :
5227423
シーケンス:
Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

安全性情報

WGK Germany  3

5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01BCS4011661
(Leu15)-Gastrin I (human) 		39024-57-2 1mg ￥79000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01BCS4011661
(Leu15)-Gastrin I (human) 		39024-57-2 5mg ￥315000 2024-03-01 購入
Sigma-Aldrich Japan G9145 [ロイシン15]-ガストリンI、ヒト ≥95% (HPLC)
[Leu15]-Gastrin I human ≥95% (HPLC)		 39024-57-2 0.1mg ￥27100 2024-03-01 購入
Sigma-Aldrich Japan G9145 [ロイシン15]-ガストリンI、ヒト ≥95% (HPLC)
[Leu15]-Gastrin I human ≥95% (HPLC)		 39024-57-2 0.5mg ￥86600 2024-03-01 購入
Sigma-Aldrich Japan G9145 ≥95% (HPLC)
[Leu15]-Gastrin I human ≥95% (HPLC)		 39024-57-2 .5mg ￥66800 2018-12-25 購入

5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2 化学特性,用途語,生産方法

使用

Gastrin has been used:
  • as a medium supplement establish enteroid cultures
  • as a supplement to standard Dulbecco′s Modified Eagle Medium (DMEM) culture medium, human minigut medium to establish the growth of crypts.

一般的な説明

GAST gene encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2. G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin. Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR). Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin. Gastric adenocarcinoma show high levels of gastrin.

Biochem/physiol Actions

Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu15 replaces Met15, that is readily oxidized resulting in loss of biological activity.

5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2 上流と下流の製品情報

原材料

準備製品

5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2 生産企業

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39024-57-2(5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2)キーワード:

オキシントモズジュリン 5-オキソ-L-Pro-L-Arg-L-Pro-L-Pro-L-Met-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Met-L-Asp-L-Phe-NH2 Nα-(α-アスパルチル)-L-フェニルアラニンアミド N-(4-カルボキシ-1-オキソブチル)-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-αAsp-L-Phe-NH2 5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2
  • 39024-57-2
  • H-PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
  • [LEU15]-GASTRIN I
  • PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
  • PGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
  • leu(15)-gastrinheptadecapeptid
  • 18-(5-Oxo-L-proline)-22-L-leucine-32-L-leucine-18-34-gastrinI【pig】
  • 5-Oxo-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2
  • (Leu15)-Gastrin I (huMan) (Leu15)-Gastrin-17 I (huMan), (Pyr18,Leu22,Leu32)-Gastrin I (18-34) (porcine)
  • (Leu15)-Gastrin-17 I (huMan), (Pyr18,Leu22,Leu32)-Gastrin I (18-34) (porcine)
  • [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human
  • [Leu15]-HG-17
  • [Leucine15]-Gastrin I heptadecapeptide
  • [Leucine15]-Little gastrin I
  • LHG-17
  • (Leu15)-Gastrin-17 I (human)
  • 18-34-Gastrin I (pig), 18-(5-oxo-l-proline)-22-l-leucine-32-l-leucine-
  • [15-leucine]-gastrin i, human heptadecapeptide
  • gastrin heptadecapeptide, Leu(15)-
  • gastrin I, human Leu15
  • [15-leucine]gastrin I, human
  • [15-Leucine]-Gastrin I, human heptadecapeptide, [Leu15]-Gastrin I, human, [Leu15]-HG-17, [Leucine15]-Gastrin I heptadecapeptide, [Leucine15]-Little gastrin I, LHG-17, [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human
  • (15-LEUCINE) HUMAN GASTRIN I
  • (LEU15)-GASTRIN I (HUMAN)
  • L-Phenylalaninamide, 5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-leucyl-L-α-aspartyl-
  • Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2
  • (Leu??)-Gastrin I (human)
  • 18-(5-オキソ-L-プロリン)-22-L-ロイシン-32-L-ロイシン-18-34-ガストリンI【ブタ】
  • 5-オキソ-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2
  • (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-カルバモイル-2-フェニルエチル]カルバモイル}-2-カルボキシエチル]カルバモイル}-3-メチルブチル]カルバモイル}-2-(1H-インドール-3-イル)エチル]カルバモイル}メチル)カルバモイル]-2-(4-ヒドロキシフェニル)エチル]カルバモイル}エチル]カルバモイル}-3-カルボキシプロピル]カルバモイル}-3-カルボキシプロピル]カルバモイル}-3-カルボキシプロピル]カルバモイル}-3-カルボキシプロピル]カルバモイル}-4-[(2S)-2-[(2S)-3-(1H-インドール-3-イル)-2-{[(2S)-1-(2-{[(2S)-5-オキソピロリジン-2-イル]ホルムアミド}アセチル)ピロリジン-2-イル]ホルムアミド}プロパンアミド]-4-メチルペンタンアミド]ブタン酸
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