3-Oxocyclobutanecarboxylic acid
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3-Oxocyclobutanecarboxylic acid 속성
- 녹는점
- 69-70℃
- 끓는 점
- 296°C
- 밀도
- 1.431
- 인화점
- 147°C
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.35±0.20(Predicted)
- 색상
- 회백색
- 수용성
- 물에 약간 용해됩니다.
- InChI
- InChI=1S/C5H6O3/c6-4-1-3(2-4)5(7)8/h3H,1-2H2,(H,7,8)
- InChIKey
- IENOFRJPUPTEMI-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)CC(=O)C1
- CAS 데이터베이스
- 23761-23-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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| 유해·위험 문구: |
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3-Oxocyclobutanecarboxylic acid C화학적 특성, 용도, 생산
화학적 성질
White solid용도
3-Oxocyclobutanecarboxylic Acid (cas# 23761-23-1) is a compound useful in organic synthesis.주요 응용
3-Oxocyclobutanecarboxylic acid is a very important medicine intermediate, it is widely applied in the synthetic of tens kinds of bulk drugs, such as ACK1 antibody, the MDM2 antagonist, the JAK inhibitor, CETP inhibitor, kinase inhibitor, the PDE10 inhibitor, thrombin inhibitors and in autoimmunization chronic inflammatory diseases and antitumor drug, all being used to.제조 방법
The target product 3-oxocyclobutanecarboxylic acid is obtained by adopting acetone, bromine, and malononitrile as raw materials, adopting ethanol, DMF (dimethyl formamide), and water as solvents, adopting sodium iodide as an activating agent and tetrabutylammonium bromide (TBAB) as a phase transfer catalyst through three-step reaction.Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 3841, 1988 DOI: 10.1021/jo00251a0333-Oxocyclobutanecarboxylic acid 준비 용품 및 원자재
원자재
준비 용품
3,3-Difluorocyclobutanecarboxylic acid
5,8-Dioxaspiro[3.4]octane-2-Methanol
Methyl 3-broMocyclobutane-1-carboxylate
3-BroMocyclobutanone
3-Hydroxy-cyclobutanecarboxylic acid ethyl ester
Methyl cis-3-hydroxycyclobutanecarboxylate
Carbamic acid, (3-hydroxycyclobutyl)-, 1,1-dimethylethyl ester (9CI)
3-METHYLENECYCLOBUTANECARBOXYLIC ACID
3-Oxo-cyclobutanecarboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester
isopropyl3-oxocyclobutane-1-carboxylate
Cyclobutanecarboxamide, N,N-dimethyl-3-oxo-, diethyl acetal (6CI)
3,3-difluorocyclobutane-1-carbonyl chloride
N-((3-chloropyrazin-2-yl)Methyl)-3-oxocyclobutanecarboxaMide
3-Oxocyclobutanecarboxylic acid 공급 업체
글로벌( 501)공급 업체
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