关附壬素
| 中文名称 | 关附壬素 |
|---|---|
| 中文同义词 | 关附壬素 |
| 英文名称 | Hetisan-2,11,13,14-tetrol,2-acetate, (2a,11a,13R)- |
| 英文同义词 | Hetisan-2,11,13,14-tetrol,2-acetate, (2a,11a,13R)-;Hetisan-2,11,13,14-tetrol, 2-acetate, (2α,11α,13R)- |
| CAS号 | 110225-59-7 |
| 分子式 | C22H29NO5 |
| 分子量 | 387.48 |
| EINECS号 | |
| 相关类别 | 对照品;生物碱 |
| Mol文件 | 110225-59-7.mol |
| 结构式 |  |
关附壬素 性质
| 沸点 | 551.8±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.48±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 13.30±0.70(Predicted) |
Guanfu base I (Acorine) 是 Guanfu base A 的活性代谢产物，是从 Aconitum coreanum 中分离得到的，具有很强的抗心律失常的作用。
The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined. The method is linear in the 0.05-20 μg/mL concentration range. The recovery of Guanfu base I is more than 80%. The intraday and interday precision, expressed as the relative standard deviation, is generally good. After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours. The total plasma clearance value is 1.46 L/h/kg. After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour. The absolute bioavailability of Guanfu base I is 71.31%.