别孕烯醇酮
中文名称 | 别孕烯醇酮 |
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中文同义词 | 异孕烷醇酮;1-[(8R,9S,10S,13S,14S,17S)-3-羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊烷并[A]菲-17-基]乙酮;别孕烷醇酮;别孕烯醇酮 别孕酮中间体;5ALPHA-孕甾-3BETA-醇--20-酮,四氢孕酮非标;5ALPHA-孕甾-3BETA-醇-20-酮,四氢孕酮(17A,21,21,21-D4,97%+)96%PURE;5ALPHA-孕甾-3BETA-醇-20-酮;2H4]-异孕酮 |
英文名称 | ALLOPREGNANOLONE |
英文同义词 | 3-beta-hydroxy-5-alpha-pregnan-20-on;3-hydroxy-,(3-beta,5-alpha)-pregnan-20-on;3-Hydroxypregnan-20-one;5alpha-Pregnan-20-one, 3beta-hydroxy-;5alpha-Pregnane-3beta-ol-20-one;Allopregnan-3beta-ol-20-one;Allopregnane-3beta-ol-20-one;Pregnan-20-one, 3-hydroxy-, (3beta,5alpha)- |
CAS号 | 516-55-2 |
分子式 | C21H34O2 |
分子量 | 318.49 |
EINECS号 | 208-224-2 |
相关类别 | 中药对照品;别孕酮中间体;Steroids |
Mol文件 | 516-55-2.mol |
结构式 |
别孕烯醇酮 性质
熔点 | 200℃ |
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比旋光度 | D27 +91.2° (c = 0.4 in ethanol) |
沸点 | 431.2±18.0 °C(Predicted) |
密度 | 1.1 g/cm3 |
储存条件 | Refrigerator |
溶解度 | 可溶于氯仿(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 15.12±0.70(Predicted) |
颜色 | 白色至类白色 |
CAS 数据库 | 516-55-2(CAS DataBase Reference) |
Human Endogenous Metabolite
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On day 2, pretreatment with a 0.20 mg/kg dose of Alloepipregnanolone blocks the development of rapid tolerance to the anxiolytic effect of ethanol. However, there is a significant decrease in the anxiolytic effect in the control groups that received ethanol on both days (EE), suggesting that the 1.5 g/kg dose of ethanol results in rapid tolerance. The post hoc analysis confirms that the 0.20 mg/kg pretreatment with Alloepipregnanolone blocks the rapid tolerance compared to the control groups, although the 0.10 mg/kg dose only partially blocks the development of such tolerance. However, the 0.05 mg/kg dose has no effect on the development of rapid tolerance to ethanol.
安全信息
RTECS号 | TU4383200 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-16729A | Relenopride hydrochloride | 1 mg | 1363元 | |
2024/04/30 | HY-16729A | 别孕烯醇酮 Relenopride hydrochloride | 516-55-2 | 10mg | 4800元 |