ChemicalBook CAS DataBase List 2-Chloro-4,5-difluorobenzoic acid

2-Chloro-4,5-difluorobenzoic acid synthesis

8synthesis methods

Product Name:2-Chloro-4,5-difluorobenzoic acid
CAS Number:110877-64-0
Molecular formula:C7H3ClF2O2
Molecular Weight:192.55

121872-94-4
88 suppliers
$15.00/5g

110877-64-0
224 suppliers
$5.00/1g

Yield:110877-64-0 85.1%

Reaction Conditions:

with hydrogenchloride;sodium hypochlorite in dichloromethane;

Steps:

2 Preparation of 2-chloro-4,5-difluorobenzoic acid

EXAMPLE 2 Preparation of 2-chloro-4,5-difluorobenzoic acid To 19.1 g (0.1 mol) of 2-chloro-4,5-difluoroacetophenone, 280.4 g (0.4 mol) of a 12% sodium hypochlorite aqueous solution was added, and the mixture was reacted under reflux for 4 hours. After cooling, concentrated hydrochloric acid was dropwise added thereto until the pH became 1. The formed white crystals were dissolved in methylene chloride and separated from the aqueous phase. The separated aqueous phase was extracted twice with methylene chloride, and the extracts were added to the oil phase. Then, the solvent was distilled off to obtain 16.4 g (yield: 85.1%) of 2-chloro-4,5-difluorobenzoic acid as white crystal.

References:

US4994610,1991,A

83506-93-8 Synthesis