ChemicalBook CAS DataBase List 3-(1,3,4-OXADIAZOL-2-YL)ANILINE

3-(1,3,4-OXADIAZOL-2-YL)ANILINE synthesis

4synthesis methods

Product Name:3-(1,3,4-OXADIAZOL-2-YL)ANILINE
CAS Number:5378-35-8
Molecular formula:C8H7N3O
Molecular Weight:161.16

5565-72-0 Synthesis

5565-72-0
33 suppliers
$212.00/1 g

5378-35-8
40 suppliers
$65.00/50mg

Yield: 100%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; for 16 h;

Steps:

4.B Step B: 3-(1,3,4-oxadiazol-2-yl)aniline.
A mixture of 2-(3-nitrophenyl)-l ,3,4-oxadiazole (1 g, 5.2 mmol) and 10% palladium on carbon (0.1 g) in methanol (20 mL) was stirred at r.t. for 16 h under the atmosphere of hydrogen. The mixture was filtered through Celite and the filtrate was concentrated to give the desired compound (840 mg, quant.). MS: 162.2 (M+l)⁺.

References:

AGIOS PHARMACEUTICALS, INC.;Popovici-Muller, Janeta;SAUNDERS, Jeffrey, O.;SALITURO, Francesco, G.;CAI, Zhenwei;YAN, Shunqi;ZHOU, Ding WO2013/107405, 2013, A1 Location in patent:Paragraph 65

5565-72-0 Synthesis

5565-72-0
33 suppliers
$212.00/1 g

35219-13-7 Synthesis