ChemicalBook CAS DataBase List 3-(4-TRIFLUOROMETHYL)PHENYLPYRIDINE

3-(4-TRIFLUOROMETHYL)PHENYLPYRIDINE synthesis

13synthesis methods

Product Name:3-(4-TRIFLUOROMETHYL)PHENYLPYRIDINE
CAS Number:426823-25-8
Molecular formula:C12H8F3N
Molecular Weight:223.19

626-60-8 Synthesis

626-60-8
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$13.00/5g

128796-39-4 Synthesis

128796-39-4
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$10.00/5g

426823-25-8
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Yield:426823-25-8 99%

Reaction Conditions:

Stage #1: 3-Chloropyridine;4-trifluoromethylphenylboronic acidwith palladium diacetate;(R)-6-dicyclohexylphoshino-6'-diphenylphosphino-3,3'-dimethoxy-2,2',4,4'-tetramethyl-1,1'-biphenyl in dodecane;butan-1-ol at 25; for 0.0833333 h;Glovebox;Inert atmosphere;Suzuki-Miyaura Coupling;
Stage #2: with cesiumhydroxide monohydrate in dodecane;water;butan-1-ol at 80; for 4 h;Glovebox;Inert atmosphere;Suzuki-Miyaura Coupling;

References:

Yang, Junfeng;Liu, Sijia;Zheng, Jian-Feng;Zhou, Jianrong [European Journal of Organic Chemistry,2012,# 31,p. 6248 - 6259,12] Location in patent:supporting information

626-55-1 Synthesis