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Phthalazinone pyrazole

化学構造式
880487-62-7
CAS番号.
880487-62-7
化学名:
别名:
英語名:
Phthalazinone pyrazole
英語别名:
Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
CBNumber:
CB72592005
化学式:
C18H15N5O
分子量:
317.34
MOL File:
880487-62-7.mol

Phthalazinone pyrazole 物理性質

沸点 :
557.7±52.0 °C(Predicted)
比重(密度) :
1.35±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
insoluble in EtOH; insoluble in H2O; ≥7.14 mg/mL in DMSO
外見 :
crystalline solid
酸解離定数(Pka):
13.83±0.10(Predicted)

安全性情報

Phthalazinone pyrazole 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

Phthalazinone pyrazole 化学特性,用途語,生産方法

説明

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). It does not inhibit Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).

Phthalazinone pyrazole 上流と下流の製品情報

原材料

準備製品

Phthalazinone pyrazole 生産企業

Global( 32)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32686 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49739 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3136 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994
 2853530910@QQ.com China 8011 62
Shanghai Yu Ben Biotechnology Co., Ltd. 15502154572
 yuben012@sina.com China 504 58
DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9414 58
Changzhou Chenhong Biotechnology Co., Ltd. 0519-85788828 13775037613
 sales@chemrenpharm.com China 3553 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11289 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721
 3525679403@qq.com China 3695 58

  スペクトルデータ(1HNMR)

Phthalazinone pyrazole(880487-62-7)1HNMR
  • 880487-62-7
  • Phthalazinone pyrazole
  • Phthalazinone pyrazole Exclusive
  • 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one
  • 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-
  • 4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one
  • Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
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