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Phthalazinone pyrazole

Phthalazinone pyrazole 구조식 이미지

카스 번호:: 880487-62-7

상품명:: Phthalazinone pyrazole

동의어(영문):: Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition

CBNumber:: CB72592005

분자식:: C18H15N5O

포뮬러 무게:: 317.34

MOL 파일:: 880487-62-7.mol

속성

안전

용도

공급 업체 32

Phthalazinone pyrazole 속성

끓는 점: 557.7±52.0 °C(Predicted)

밀도: 1.35±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: insoluble in EtOH; insoluble in H2O; ≥7.14 mg/mL in DMSO

물리적 상태: 결정질 고체

산도 계수 (pKa): 13.83±0.10(Predicted)

안전

Phthalazinone pyrazole C화학적 특성, 용도, 생산

개요

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC₅₀ = 31 nM). It does not inhibit Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC₅₀ = 7.8, 2.9, and 1.6 μM, respectively).

Phthalazinone pyrazole 준비 용품 및 원자재

원자재

준비 용품

Phthalazinone pyrazole 공급 업체

글로벌( 32)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8012	62
Shanghai Yu Ben Biotechnology Co., Ltd.	15502154572	yuben012@sina.com	China	505	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	sales@chemrenpharm.com	China	3553	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3695	58