Phthalazinone pyrazole

880487-62-7

CAS-Nr.: 880487-62-7

Englisch Name:: Phthalazinone pyrazole

Synonyma:: Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition

CBNumber:: CB72592005

Summenformel:: C18H15N5O

Molgewicht:: 317.34

MOL-Datei:: 880487-62-7.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 32

Phthalazinone pyrazole Eigenschaften

Siedepunkt:: 557.7±52.0 °C(Predicted)

Dichte: 1.35±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: insoluble in EtOH; insoluble in H2O; ≥7.14 mg/mL in DMSO

Aggregatzustand: crystalline solid

pka: 13.83±0.10(Predicted)

Sicherheit

Phthalazinone pyrazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC₅₀ = 31 nM). It does not inhibit Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC₅₀ = 7.8, 2.9, and 1.6 μM, respectively).

Phthalazinone pyrazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Phthalazinone pyrazole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 32)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8012	62
Shanghai Yu Ben Biotechnology Co., Ltd.	15502154572	yuben012@sina.com	China	505	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	sales@chemrenpharm.com	China	3553	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3695	58

Phthalazinone pyrazole
Phthalazinone pyrazole Exclusive
4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one
1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-
4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one
Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
880487-62-7
88048-62-7