Phthalazinone pyrazole
- CAS No.
- 880487-62-7
- Chemical Name:
- Phthalazinone pyrazole
- Synonyms
- Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
- CBNumber:
- CB72592005
- Molecular Formula:
- C18H15N5O
- Molecular Weight:
- 317.34
- MDL Number:
- MFCD28399120
- MOL File:
- 880487-62-7.mol
- MSDS File:
- SDS
Phthalazinone pyrazole price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10735 | Phthalazinone pyrazole ≥98% | 880487-62-7 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 10735 | Phthalazinone pyrazole ≥98% | 880487-62-7 | 5mg | $302 | 2024-03-01 | Buy |
| Cayman Chemical | 10735 | Phthalazinone pyrazole ≥98% | 880487-62-7 | 10mg | $535 | 2024-03-01 | Buy |
| ApexBio Technology | C3823 | Phthalazinonepyrazole | 880487-62-7 | 1mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | C3823 | Phthalazinonepyrazole | 880487-62-7 | 5mg | $269 | 2021-12-16 | Buy |
Phthalazinone pyrazole Chemical Properties,Uses,Production
Description
Three Aurora kinases, A-
in vitro
phthalazinone pyrazole potently inhibited the activity of aurora a kinase with an ic50 of 31 nm. it showed no inhibitory effect on aurora b kinase at doses up to 100 μm. phthalazinone pyrazole inhibited the proliferation of hct116, colo205, and mcf-7 cells with ic50 values of 7.8, 2.9, and 1.6 μm, respectively [1].
References
[1] prime m e, courtney s m, brookfield f a, et al. phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of aurora-a kinase[j]. journal of medicinal chemistry, 2010, 54(1): 312-319.
[2] vader g, lens s m a. the aurora kinase family in cell division and cancer[j]. biochimica et biophysica acta (bba)-reviews on cancer, 2008, 1786(1): 60-72.
Phthalazinone pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
Phthalazinone pyrazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
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